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Index > Protein center > Wwox(Gene name) > Mouse
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  • Wwox (Gene name),
  • WW domain-containing oxidoreductase (Protein name ),  WWOX_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Wwox(Wox1);
    Protein name:
    WW domain-containing oxidoreductase;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TP53, TP73/p73 and MAPK8. Interacts with MAPT/TAU. Forms a ternary complex with TP53 and MDM2 and interacts with ERBB4, LITAF and WBP1. May interact with COTE1 and SCOTIN (By similarity). Interacts with HYAL2 and RUNX2. Interacts with TNK2.
    Function:
    Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development.
    Subcellular Location:
    Cytoplasm Nucleus Mitochondrion Partially localizes to the mitochondria (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity). Translocates to the nucleus upon genotoxic stress or TNF stimulation.
    Protein Attributes:
    Sequence length:
    414
    Sequence:
    50:
    MAALRYAGLD | DTDSEDELPP | GWEERTTKDG | WVYYANHTEE | KTQWEHPKTG | 
    100:
    KRKRVAGDLP | YGWEQETDEN | GQVFFVDHIN | KRTTYLDPRL | AFTVDDNPTK | 
    150:
    PTTRQRYDGS | TTAMEILQGR | DFTGKVVLVT | GANSGIGFET | AKSFALHGAH | 
    200:
    VILACRNLSR | ASEAVSRILE | EWHKAKVEAM | TLDLAVLRSV | QHFAEAFKAK | 
    250:
    NVSLHVLVCN | AGTFALPWGL | TKDGLETTFQ | VNHLGHFYLV | QLLQDVLCRS | 
    300:
    SPARVIVVSS | ESHRFTDIND | SSGKLDLSRL | SPPRSDYWAM | LAYNRSKLCN | 
    350:
    ILFSNELHRR | LSPRGVTSNA | VHPGNMMYSA | IHRNSWVYKL | LFTLARPFTK | 
    400:
    SMQQGAATTV | YCAVAPELEG | LGGMYFNNCC | RCLPSEEAQS | EETARALWEL | 
    414:
    SERLIQDRLG | SPSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse WW domain-containing oxidoreductase
    Cat.:
    E2982h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse WW domain-containing oxidoreductase
    Cat.:
    E2982c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse WW domain-containing oxidoreductase
    Cat.:
    E2982m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse WW domain-containing oxidoreductase
    Cat.:
    U2982h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse WW domain-containing oxidoreductase
    Cat.:
    U2982c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse WW domain-containing oxidoreductase
    Cat.:
    U2982m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse WW domain-containing oxidoreductase
    Polyclonal Antibody for Mouse WW domain-containing oxidoreductase
    Cat.:
    P2982Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse WW domain-containing oxidoreductase
    Cat.:
    P2982Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse WW domain-containing oxidoreductase
    Monoclonal Antibody for Mouse WW domain-containing oxidoreductase
    Monoclonal Antibody for Mouse WW domain-containing oxidoreductase
    Protein for Mouse WW domain-containing oxidoreductase
    Protein for Mouse WW domain-containing oxidoreductase
    Protein for Mouse WW domain-containing oxidoreductase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity."
      Chang N.-S. , Pratt N. , Heath J. , Schultz L. , Sleve D. , Carey G.B. , Zevotek N.
      J. Biol. Chem.276:3361-3370(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INDUCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF 51-LYS--ARG-54;DOMAIN;INTERACTION WITH TP53
      tissue: Fibroblast.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Colon.
      tissue: Embryo.
      tissue: Pituitary.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: FVB/N.
      tissue: Kidney.
    4. 4.
      "The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1."
      Krummel K.A. , Denison S.R. , Calhoun E. , Phillips L.A. , Smith D.I.
      Genes Chromosomes Cancer34:154-167(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-414
    5. 5.
      "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis."
      Chang N.-S. , Doherty J. , Ensign A.
      J. Biol. Chem.278:9195-9202(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK8 AND TP53
    6. 6.
      "Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease."
      Sze C.-I. , Su M. , Pugazhenthi S. , Jambal P. , Hsu L.-J. , Heath J. , Schultz L. , Chang N.-S.
      J. Biol. Chem.279:30498-30506(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPT
    7. 7.
      "Phosphoproteomic analysis of the developing mouse brain."
      Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
      Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic brain.
    8. 8.
      "Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system."
      Chen S.-T. , Chuang J.-I. , Wang J.P. , Tsai M.S. , Li H. , Chang N.-S.
      Neuroscience124:831-839(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
    9. 9.
      "WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53."
      Chang N.-S. , Doherty J. , Ensign A. , Schultz L. , Hsu L.-J. , Hong Q.
      J. Biol. Chem.280:43100-43108(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53;DOMAIN
    10. 10.
      "Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidoreductase in vivo."
      Chen S.-T. , Chuang J.-I. , Cheng C.-L. , Hsu L.-J. , Chang N.-S.
      Neuroscience130:397-407(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
    12. 12.
      "The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism."
      Aqeilan R.I. , Hassan M.Q. , de Bruin A. , Hagan J.P. , Volinia S. , Palumbo T. , Hussain S. , Lee S.-H. , Gaur T. , Stein G.S. , Lian J.B. , Croce C.M.
      J. Biol. Chem.283:21629-21639(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
    13. 13.
      "Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1."
      Hsu L.-J. , Schultz L. , Hong Q. , Van Moer K. , Heath J. , Li M.-Y. , Lai F.-J. , Lin S.-R. , Lee M.-H. , Lo C.-P. , Lin Y.-S. , Chen S.-T. , Chang N.-S.
      J. Biol. Chem.284:16049-16059(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-33;SUBCELLULAR LOCATION;INTERACTION WITH HYAL2
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